L'essentiel sur "Autisme et Inclusion"

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Fri Feb 3 05:30:02 CET 2023 France - It's time to Stand Up! For inclusion
31/01/23 L'Arche: l'emprise de Jean Vanier confirmee par une enquete [informations.handicap]
31/01/23 Research Project Focuses on Promoting Dual-Language Development for Children with Autism in Bilingual Families : UMass Amherst [umass]
26/01/23 Anxiete des adolescents : « il est temps d'organiser une prevention adaptee » | Cerveau & Psycho [cerveauetpsycho]
25/01/23 Evolution de la PCH : La CNSA publie un guide pour accompagner les MDPH| CNSA [cnsa]
21/01/23 Free autism questionnaire can help diagnose children, research says | [ksl]
21/01/23 The Autism Symptom Dimensions Questionnaire: Development and psychometric evaluation of a new, open-source measure of autism symptomatology - PubMed [pubmed.ncbi.nlm.nih]
20/01/23 Predire l'apparition de troubles anxieux grace a l'IA [informations.handicap]
17/01/23 ADHD found to be more predictive of poor mental health outcomes in adults [news-medical]
17/01/23 GI Conditions Can Worsen Autism Symptoms, And Vice Versa - Gastroenterology & Endoscopy News [gastroendonews]
17/01/23 Cohort-guided insights into gene-environment interactions in autism spectrum disorders | Nature Reviews Neurology [nature]
13/01/23 Brain wiring explains why autism hinders grasp of vocal emotion, says Stanford Medicine study | News Center | Stanford Medicine [med.stanford]
12/01/23 Alerte ethique : decryptage de la nouvelle procedure de recueil [lagazettedescommunes]
09/01/23 Parent-rated anxiety in autistic adolescents and young adults: Concurrent links to autism traits and chronic sleep problems - ScienceDirect [sciencedirect]
05/01/23 Development of stigma-related support for autistic adults: Insights from the autism community - Emeline Han, Katrina Scior, Eric Heath, Kana Umagami, Laura Crane, 2023 [journals.sagepub]
05/01/23 Protection de l'enfance : de nouveaux outils pour harmoniser les pratiques [banquedesterritoires]
04/01/23 La population des enfants suivis en protection de l’enfance au 31 décembre 2020 : les disparités départementales [onpe.gouv]
31/12/22 Decret n° 2022-1773 du 30 decembre 2022 relatif au tarif horaire minimal de l'aide a domicile mentionne au I de l'article L. 314-2-1 du code de l'action sociale et des familles pour l'annee 2023 - Legifrance [legifrance.gouv]
22/12/22 Un lien entre la perte auditive et les troubles du spectre autistique | Le Club [blogs.mediapart]
21/12/22 A Link Between Hearing Loss and Autism Spectrum Disorder - Neuroscience News [neurosciencenews]
13/12/22 Intense World Theory Of Autism Explained Simply [spring.org]
13/12/22 La decouverte pourrait conduire a des cibles therapeutiques pour traiter l'hyperphagie boulimique et l'obesite - Actualites Psychologie et psychiatrie [actualite.housseniawriting]
09/12/22 Trouble du spectre autistique : un mecanisme de compensation pourrait etre present dans certains neurones [radiofrance]
07/12/22 Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways - Lefebvre - Autism Research - Wiley Online Library [onlinelibrary.wiley]
07/12/22 Autism related language preferences of English speaking individuals across the globe: A mixed methods investigation - Keating - Autism Research - Wiley Online Library [onlinelibrary.wiley]
06/12/22 Neuromagnetic 40 Hz auditory steady-state response in the left auditory cortex is related to language comprehension in children with autism spectrum disorder - PubMed [pubmed.ncbi.nlm.nih]
02/12/22 Elemental Dynamics in Hair Accurately Predict Future Autism Spectrum Disorder Diagnosis: An International Multi-Center Study [mdpi]
02/12/22 New approaches to clinical electroencephalography analysis in typically developing children and children with autism - ScienceDirect [sciencedirect]
30/11/22 *** Relations between language, non-verbal cognition, and conceptualization in non- or minimally verbal individuals with ASD across the lifespan - Dominika Slusna, Andrea Rodriguez, Berta Salvado, Agustin Vicente, Wolfram Hinzen, 2021 [journals.sagepub]
29/11/22 Social Gene and Anti-Social Antibiotic Uncovered in Animal Study May Aid Autism Research [genengnews]
28/11/22 GUIDE PRATIQUE -Association des Maires de France AGIR POUR L’INCLUSION DES PERSONNES AUTISTES [amf.asso]
16/11/22 New evidence hints at mechanisms for ...˜fever effect' in autism | Spectrum | Autism Research News [spectrumnews]
11/11/22 Sensitivity to interaural level and time differences in individuals with autism spectrum disorder | Scientific Reports [nature]
07/11/22 Eczema linked to increased symptom severity in children with autism spectrum disorder [psypost]

L'Arche: l'emprise de Jean Vanier confirmee par une enquete 31/01/2023


«Une enquête indépendante commandée par L'Arche, publiée le 30 janvier 2023, confirme la large "emprise" qu'a pu exercer Jean Vanier, figure spirituelle catholique décédée en 2019 et accusée d'agressions sexuelles dans un rapport de 2020.31 janvier 2023 ... En février 2020, l'information avait provoqué une onde de choc dans le milieu catholique : l'Arche, une fédération d'associations fondée par Jean Vanier et qui accueille dans 38 pays des personnes ayant une déficience intellectuelle, avait dévoilé un rapport interne mené par un organisme indépendant (Lire : Révélations Jean Vanier : résidents de l'Arche sous le choc ). Ce dernier révélait que Jean Vanier avait eu avec six femmes adultes (et non handicapées), dont certaines vulnérables, "des relations sexuelles, généralement dans le cadre d'un accompagnement spirituel, et dont certaines ont gardé de profondes blessures"»...

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informations.handicap

Research Project Focuses on Promoting Dual-Language Development for Children with Autism in Bilingual Families : UMass Amherst 31/01/2023

«A University of Massachusetts Amherst researcher has been awarded a National Institutes of Health (NIH) grant to study bilingualism in children with autism spectrum disorder (ASD) whose household speaks a language other than English."This is a group that often is excluded from existing research or intervention studies," says Megan Gross, assistant professor of communication disorders in the School of Public Health and Health Sciences. "And I think there's still a lot of misinformation that can get out there to bilingual families about what language to speak at home with their child." To make it possible to include children who do not speak, Gross will use innovative eye-tracking technology to analyze their ability to comprehend bilingual spoken language. A camera at the bottom of a laptop computer will track the child’s eye movement as a word or phrase in English and Spanish is played out loud.»
[...]
«Gross will examine the type of bilingual environment to which children with ASD, ages 4-6, are exposed, as well as the different factors that relate to their ability to speak or understand both Spanish and English. She will also consider the children’s social communication and social-cognitive skills, such as cognitive flexibility, as well as their ability to understand and communicate in two languages. To make it possible to include children who do not speak, Gross will use innovative eye-tracking technology to analyze their ability to comprehend bilingual spoken language. A camera at the bottom of a laptop computer will track the child’s eye movement as a word or phrase in English and Spanish is played out loud. “By following their eye movements over time, we can tell whether they’ve understood the word or phrase that they heard because they should look at the corresponding picture,” Gross says. “This is a group I’m especially interested in including in my study. Even if they are not speaking, we need a way to measure what they are understanding when people are speaking to them in Spanish and English. And what skills might they have that they aren’t able to show us through their spoken language?” »...

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umass

Anxiete des adolescents : « il est temps d'organiser une prevention adaptee » | Cerveau & Psycho 26/01/2023

«Jean-Luc Martinot, vous venez de montrer que l'on peut évaluer scientifiquement le risque qu'un adolescent âgé de 14 ans développe plus tard des troubles anxieux. Mais tout adolescent est plus ou moins anxieux. Alors, de quoi parle-t-on exactement ?Il s'agit d'«Â angoisse » - autrefois, on parlait de «Â névrose » -, une caractéristique commune à tous les troubles dits «Â anxieux », comme le trouble panique, le trouble d'anxiété sociale, le trouble anxieux généralisé, les phobies et les TOC. Environ un adolescent sur trois serait concerné, mais la plupart de ces maladies mentales se développent progressivement, de sorte que, en général, on ne peut poser de diagnostic psychiatrique qu'à la fin de l'adolescence ou au début de l'âge adulte, entre 18 et 25 ans.»
[...]
« Dans notre pays, on dispose d’un programme de repérage précoce et d’intervention brève pour des addictions ou des « usages à risque », mais il concerne plutôt les individus de 25 ans et au-delà : c’est vraiment tard ! Je le dis à nouveau : avant 16 ans, le cerveau est dans une période de vulnérabilité, mais aussi de plasticité. Entre 18 et 25 ans, sa dynamique de transition vers l’âge adulte est en cours. Plus on attend, plus des symptômes psychopathologiques isolés risquent de s’inscrire durablement et d’évoluer vers des troubles mentaux cliniques. La recherche et l’évaluation d’interventions préventives adaptées seraient donc un moyen de soulager le système de soins psychiatrique, qui, malheureusement, est saturé. Or il y a déjà des outils de détection validés et quelques interventions contrôlées à l’étranger, qui présentent un bon rapport coût-benéfice : reste maintenant à organiser et évaluer, en France, la prévention. »...

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cerveauetpsycho

Evolution de la PCH : La CNSA publie un guide pour accompagner les MDPH| CNSA 25/01/2023

«Le décret n° 2022-570 du 19 avril 2022 relatif à la prestation de compensation prévoit d'améliorer l'accès à la PCH pour les personnes ayant une altération de fonctions mentales, psychiques, cognitives ou un trouble neurodéveloppemental (TND) à partir du 1er janvier 2023. La CNSA publie un guide pour accompagner les équipes pluridisciplinaires des maisons départementales des personnes handicapées (MDPH) dans leur mise en oeuvre de cette évolution.L'amélioration de l'accès aux droits et à la compensation des personnes vivant avec une altération des fonctions mentales, psychiques, cognitives ou avec un TND a été identifiée comme une priorité forte lors de la Conférence nationale du handicap (CNH) du 11 février 2020.Le décret du 19 avril 2022 fait suite au rapport de synthèse pour un décret d'adaptation du référentiel d'accès à la PCH pour les personnes en situation de handicap du fait d'altérations des fonctions mentales, cognitives, psychiques (nouvelle fenêtre, PDF, 7.91 Mo), publié en mai 2021 par l'Union nationale de familles et amis de personnes malades et/ou handicapées psychiques (UNAFAM), Autisme France, HyperSupers TDAH et l'UNAPEI, aux propositions du rapport Leguay et à une expérimentation menée dans trois MDPH (Ardennes, Gironde, Vosges) entre octobre 2021 et mars 2022. Il vise à améliorer l'accès à la PCH pour les personnes ayant une altération de fonctions mentales, psychiques, cognitives ou avec un TND.»
[...]
« Documents à télécharger Prestation de compensation du handicap. Mise en œuvre du décret n° 2022-570 du 19 avril 2022, articles 2 et 3 - accessible (PDF, 1.48 Mo) »...
Source: http://www.cnsa.fr | Source Status

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cnsa

Evolution de la PCH : La CNSA publie un guide pour accompagner les MDPH| CNSA 25/01/2023

«Le décret n° 2022-570 du 19 avril 2022 relatif à la prestation de compensation prévoit d'améliorer l'accès à la PCH pour les personnes ayant une altération de fonctions mentales, psychiques, cognitives ou un trouble neurodéveloppemental (TND) à partir du 1er janvier 2023. La CNSA publie un guide pour accompagner les équipes pluridisciplinaires des maisons départementales des personnes handicapées (MDPH) dans leur mise en oeuvre de cette évolution.L'amélioration de l'accès aux droits et à la compensation des personnes vivant avec une altération des fonctions mentales, psychiques, cognitives ou avec un TND a été identifiée comme une priorité forte lors de la Conférence nationale du handicap (CNH) du 11 février 2020.Le décret du 19 avril 2022 fait suite au rapport de synthèse pour un décret d'adaptation du référentiel d'accès à la PCH pour les personnes en situation de handicap du fait d'altérations des fonctions mentales, cognitives, psychiques (nouvelle fenêtre, PDF, 7.91 Mo), publié en mai 2021 par l'Union nationale de familles et amis de personnes malades et/ou handicapées psychiques (UNAFAM), Autisme France, HyperSupers TDAH et l'UNAPEI, aux propositions du rapport Leguay et à une expérimentation menée dans trois MDPH (Ardennes, Gironde, Vosges) entre octobre 2021 et mars 2022. Il vise à améliorer l'accès à la PCH pour les personnes ayant une altération de fonctions mentales, psychiques, cognitives ou avec un TND.»
[...]
« Documents à télécharger Prestation de compensation du handicap. Mise en œuvre du décret n° 2022-570 du 19 avril 2022, articles 2 et 3 - accessible (PDF, 1.48 Mo) »...
Source: http://www.cnsa.fr | Source Status

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cnsa

Free autism questionnaire can help diagnose children, research says | 21/01/2023

«WEST JORDAN ...” Veronica Bernard was worried for her son, Jacob, when he was 4 years old and hadn't yet said the word "mom." She knew he was smart ...” he knew colors and shapes and could point to things ...” but he had yet to put his thoughts into words.A pediatrician suggested that Jacob be tested for autism. They got in to see a specialist after 2½ months of waiting, but Bernard said the testing took weeks."There were several appointments that were dragged on, and some of them I had to reschedule because he wouldn't cooperate or he didn't want to sit down," she said. "For a parent, that's emotionally and mentally draining." Hanna said the new questionnaire might not be enough for parents to get the services their child may need.»
[...]
« Is an official diagnosis necessary? Hanna said the new questionnaire might not be enough for parents to get the services their child may need. "The big question would be if a parent utilizes this tool, and it looks like the child may be on the spectrum, then what?" she said. "They need a formal diagnosis to access a lot of services." Rivera had suspected her son was autistic long before his clinical diagnosis, but that diagnosis opened their family up to a world of benefits. "Getting the diagnosis helped understand what was going on in his brain and how to help him and empathize … and then it helped because we were able to get into behavior therapy," Rivera said. "With behavior therapy, that came along with parent training, and parent training literally saved our family." Bernard said a medical diagnosis is required for an autistic child to receive assistance through a Utah public school. But she also pointed to many resources parents and children can access without that. "There's so much information on the internet. There are so many books now," Bernard said. "There are so many different parents advocating for so many different things if you just get on Instagram alone." Bernard also urged other parents with autistic children to go with their "parental gut instinct" when it comes to dealing with teachers and doctors. "Keep fighting," she said. "Keep fighting for your kids, because it's going to amount to something someday, and then in turn, they're going to learn how to fight too." »...

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ksl

The Autism Symptom Dimensions Questionnaire: Development and psychometric evaluation of a new, open-source measure of autism symptomatology - PubMed 21/01/2023

«AbstractAim: To describe the development and initial psychometric evaluation of a new, freely available measure, the Autism Symptom Dimensions Questionnaire (ASDQ).Method: After development and revision of an initial 33-item version, informants completed a revised 39-item version of the ASDQ on 1467 children and adolescents (aged 2-17 years), including 104 with autism spectrum disorder (ASD). Results: The initial 33-item version of the ASDQ had good reliability and construct validity. However, only four specific symptom factors were identified, potentially due to an insufficient number of items. Factor analyses of the expanded instrument identified a general ASD factor and nine specific symptom factors with good measurement invariance across demographic groups. Scales showed good-to-excellent overall and conditional reliability. Exploratory analyses of predictive validity for ASD versus neurotypical and other developmental disability diagnoses indicated good accuracy for population and at-risk contexts.»
[...]
« Results: The initial 33-item version of the ASDQ had good reliability and construct validity. However, only four specific symptom factors were identified, potentially due to an insufficient number of items. Factor analyses of the expanded instrument identified a general ASD factor and nine specific symptom factors with good measurement invariance across demographic groups. Scales showed good-to-excellent overall and conditional reliability. Exploratory analyses of predictive validity for ASD versus neurotypical and other developmental disability diagnoses indicated good accuracy for population and at-risk contexts. Interpretation: The ASDQ is a free and psychometrically sound informant report instrument with good reliability of measurement across a continuous range of scores and preliminary evidence of predictive validity. The measure may be a useful alternative to existing autism symptom measures but further studies with comparison of clinical diagnoses using criterion-standard instruments are needed. ____ Téléchargements Autism Symptom Dimensions Questionnaire (ASDQ) final 220105.docx Autism Symptom Dimensions Questionnaire (ASDQ) final 220105.pdf
Source: https://osf.io | Source Status »...
Source: http://pubmed.ncbi.nlm.nih.gov | Source Status

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pubmed.ncbi.nlm.nih

Predire l'apparition de troubles anxieux grace a l'IA 20/01/2023

«L'intelligence artificielle (IA), un allié de poids pour prévenir les troubles anxieux ? Plusieurs études ont mis en évidence le pouvoir prédictif de cette technique dans le cadre de troubles psychiques comme la dépression ou les addictions. Mais aucune ne s'était penchée sur les troubles anxieux... C'est désormais chose faite. Des chercheurs du laboratoire « Trajectoires développementales et psychiatrie » (Inserm) et du Centre Borelli (CNRS) ont identifié, grâce à l'IA, des signes avant-coureurs, à l'adolescence, qui augmentent « significativement » le risque de développer des troubles anxieux à l'âge adulte. Les résultats de l'étude ont été publiés dans la revue scientifique Molecular Psychiatry en décembre 2022.»
[...]
«3 signes : neuroticisme, désespoir, symptômes émotionnels Trois signes prédicteurs majeurs ont été mis en évidence. Primo, le neuroticisme, qui désigne une tendance persistante à ressentir des émotions négatives (peur, tristesse, gêne, colère, culpabilité, dégoût...), une mauvaise maîtrise des pulsions et une inadaptation face aux stress. Secundo, le désespoir, associé à un faible score de réponses aux questions évaluant l'optimisme et la confiance en soi. Enfin, les symptômes émotionnels recouvrent les réponses indiquant des symptômes tels que « des maux de tête et d'estomac », « beaucoup de soucis, souvent inquiet », « souvent malheureux, abattu ou larmoyant », « nerveux dans les nouvelles situations, perd facilement confiance », « a facilement peur ». D'autres signes avant-coureurs ont été hiérarchisés pour chaque individu, par exemple les liens familiaux, la consommation d'alcool, la détresse, l'âge, un accident, le degré d'autonomie... Cette découverte pourrait « permettre de détecter les personnes à risque plus tôt et de leur proposer une intervention adaptée et personnalisée, tout en limitant la progression de ces pathologies et leurs conséquences sur la vie quotidienne », se félicite Jean-Luc Martinot, directeur de recherche à l'Inserm et pédopsychiatre, co-auteur de l'étude. »...

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informations.handicap

ADHD found to be more predictive of poor mental health outcomes in adults 17/01/2023

«Adults with high levels of attention-deficit hyperactivity disorder (ADHD) symptoms are more likely to experience anxiety and depression than adults with high levels of autistic traits, according to new research led by psychologists at the University of Bath in the UK.This study is the first to show that ADHD is more predictive of poor mental health outcomes in adults than other neurodevelopmental conditions, like autism.Until now, there has been a dearth of information on the effects of ADHD on poor mental health, with far more research focusing on the impact of autism on depression, anxiety and quality of life. As a result, people with ADHD have often struggled to access the clinical care they need to cope with their symptoms.The authors of the study hope their findings will trigger new research into ADHD and ultimately improve the mental health outcomes for people with the condition. ADHD is a neurodevelopmental condition characterized by inattention and/or hyperactivity and impulsivity. The condition is estimated to affect between 3% and 9% of the population»...

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news-medical

GI Conditions Can Worsen Autism Symptoms, And Vice Versa - Gastroenterology & Endoscopy News 17/01/2023

«As pediatric gastroenterologist Kara Gross Margolis, MD, was beginning her research career, an early opportunity to work with colleagues in the field of psychiatry led her ultimately to subspecialize and develop expertise in brain-gut axis disorders. That early work...”devising screening criteria to diagnose gastrointestinal conditions in patients with autism spectrum disorder...”has blossomed into a subspeciality in a pediatric community for which families seek her out.Remembering those early days, Dr. Gross Margolis told Gastroenterology & Endoscopy News, "It was really at that point that I realized just how common gastrointestinal problems were in autism. And obviously, as a gastroenterologist, it really struck a chord with me of ˜how could this be related to autism?'" Diagnosing and treating gastrointestinal complaints in children with autism spectrum disorder can be difficult but are increasingly important as more research shows that GI conditions can worsen ASD symptoms. Kara Gross Margolis, MD, who co-authored an overview of GI and ASD in Psychiatric Clinics of North America (2021;44[1]:69-81), walked us through different aspects that providers can incorporate into their office visits.»
[...]
« Tips for Managing Patients With GI Issues and ASD Diagnosing and treating gastrointestinal complaints in children with autism spectrum disorder can be difficult but are increasingly important as more research shows that GI conditions can worsen ASD symptoms. Kara Gross Margolis, MD, who co-authored an overview of GI and ASD in Psychiatric Clinics of North America (2021;44[1]:69-81), walked us through different aspects that providers can incorporate into their office visits. Understand symptoms. Many children with ASD may not be able to explain the symptoms they are experiencing. They can be nonverbal or have poor sensory localization. However, as Dr. Gross Margolis said, new-onset challenging behaviors, hyperactivity, sleep issues and worsening of other ASD symptoms could be signals of GI problems. Dr. Gross Margolis advises a full GI evaluation, at the very least with a comprehensive history and physical, and in some cases considering endoscopy. Gastrointestinal problems can be missed when clinicians do not connect GI issues to behaviors such as withdrawal, anxiety, self-injury or aggression, she said. Ask about diet. Some children with ASD may only eat extremely selectively or could be on exclusion diets to help manage symptoms. Food selectivity can be associated with GI issues, Dr. Gross Margolis said, and there are some indicators that lower food diversity in the diet can be related to changes in stool inconsistency and changes in the gut microbiota (Cell 2021;184[24]:5916-5931). “I think understanding how diet plays a role is going to be really important.” Review medications. Medications need to be fine-tuned for this patient population because many drugs prescribed for ASD symptoms can have prominent GI side effects. “We often try to figure out if there’s a medication that’s causing a GI problem, and if there’s a substitute or if it’s more important to treat that psychiatric problem with that specific medication, and maybe go to a different type of gastrointestinal treatment.” Don’t forget the supplements. Many of these patients are on a long list of supplements. Large doses or certain kinds can cause side effects. For example, individuals with ASD are often placed on probiotics and/or fish oil, she said, which can cause nausea, bloating and diarrhea. Listen to parents. “Parents know their kids,” she said, noting that this is supported by data. One study found that parents were right about their child with ASD’s GI issue 90% of the time (Autism Res 2012;5[2]:101-108). Be optimistic. Being hopeful can go a long way, especially to a family that is struggling with their child’s symptoms. Mention that research is ongoing, and new treatments and better understanding of symptom interplay are on the horizon. »...

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gastroendonews

Cohort-guided insights into gene-environment interactions in autism spectrum disorders | Nature Reviews Neurology 17/01/2023

«Abstract Prospective birth cohorts offer unprecedented opportunities to investigate the pathogenesis of complex disorders such as autism, in which gene-environment interactions must be appreciated in a temporal context. This Perspective article considers the history of autism research, including missteps that reflected an incomplete understanding of the epidemiology of autistic spectrum disorders, the effects of advocacy and philanthropy on the trajectory of scientific inquiry, and the current and future roles of prospective birth cohort research in illuminating the pathology of these and other complex disorders wherein exposures during gestation might not manifest until later in life.»
[...]
« Figure 1 shows a timeline of seminal events in the history of biomedical research in autism. Although initially characterized as psychosis74,75,76, from the 1970s onwards autism was reframed as a developmental disorder with a heritable component15,77,78,79,80,81. Various exposures were subsequently identified as contributing to the risk of autism spectrum disorder, the understanding of which continues to evolve5,16,17,19,20,25,82,83,84,85,86,87,88,89. Special projects initiated and supported by The National Alliance for Autism Research and Cure Autism Now include the Autism Tissue Program brain bank, the Autism Genetic Resource Exchange and the High-Risk Baby Siblings Consortium. »...

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nature

Brain wiring explains why autism hinders grasp of vocal emotion, says Stanford Medicine study | News Center | Stanford Medicine 13/01/2023

«Children with autism often struggle to identify emotional cues in other people's voices because of differences in the wiring and function of a key social center in their brains, according to a new study from the Stanford School of Medicine. “Children typically learn to map certain sounds in people’s voices onto particular emotions,” said the study’s co-lead author, Daniel Abrams, PhD, clinical associate professor of psychiatry and behavioral sciences at Stanford Medicine.»
[...]
« The findings, published online Jan. 9 in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, offer an explanation for the neurological origin of a key social challenge in autism. They also provide clues as to the type of therapy that might help, according to the researchers. “Children typically learn to map certain sounds in people’s voices onto particular emotions,” said the study’s co-lead author, Daniel Abrams, PhD, clinical associate professor of psychiatry and behavioral sciences at Stanford Medicine. “If Mom or Dad is unhappy, a little kid will know that before understanding all the words,” Abrams said, noting that young children recognize slow, low-pitched speech as showing sadness. “But kids with autism have trouble mapping vocal features onto emotion. Before this study, we didn’t know why the brains of people with autism have a roadblock for identifying and recognizing these vocal cues.” »...

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med.stanford

Alerte ethique : decryptage de la nouvelle procedure de recueil 12/01/2023


«Le décret du 3 octobre 2022 rappelle, après la loi, l'obligation pour les collectivités de plus de 10 000 habitants ou employant plus de 50 agents d'établir une procédure de recueil des alertes éthiques. Samuel Dyens, avocat associé au cabinet Goutal, Alibert et associés, le décrypte pour La Gazette.»...

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lagazettedescommunes

Alerte ethique : decryptage de la nouvelle procedure de recueil 12/01/2023

«Le décret du 3 octobre 2022 rappelle, après la loi, l'obligation pour les collectivités de plus de 10 000 habitants ou employant plus de 50 agents d'établir une procédure de recueil des alertes éthiques. Samuel Dyens, avocat associé au cabinet Goutal, Alibert et associés, le décrypte pour La Gazette.»...

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lagazettedescommunes

Parent-rated anxiety in autistic adolescents and young adults: Concurrent links to autism traits and chronic sleep problems - ScienceDirect 09/01/2023

«AbstractBackgroundAnxiety is prevalent among autistic individuals, but less is known about the different anxiety problems autistic adolescents and young adults experience and the main behavioral manifestations of their anxiety. This study investigated these issues and the relation between the overall level of anxiety and a range of factors in autistic adolescents and young adults, including autism traits, challenging behaviors, adaptive behavior, sleep problems, and gastrointestinal issues.Method66 parents of autistic adolescents and young adults completed an interview and responded to questionnaires on their children's anxiety, autism traits, sensory processing, challenging behaviors, adaptive behavior, and medical issues.ResultsThe most frequently parent-endorsed moderate and severe anxiety problems were related to social situations, new situations, upcoming events, loud noises, and changes in routine. In contrast, parents were least likely to endorse anxiety problems related to being separated from others, being noticed, or being late. Regarding anxiety-related behaviors, parents frequently endorsed avoidance, requiring constant reassurance, performing repetitive behaviors, shutting down, and overreacting to changes. Individuals with more severe social cognition difficulties, restricted and repetitive behaviors (RRBs), and chronic sleep problems demonstrated elevated levels of anxiety. Chronic sleep problems emerged as the primary concurrent predictor of anxiety in autistic adolescents and young adults and mediated the association between RRBs and anxiety.»
[...]
« Conclusions Future anxiety treatment should consider targeting sleep problems simultaneously for autistic adolescents and young adults. »...

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sciencedirect

Development of stigma-related support for autistic adults: Insights from the autism community - Emeline Han, Katrina Scior, Eric Heath, Kana Umagami, Laura Crane, 2023 05/01/2023

«Abstract Many autistic adults experience public stigma and some internalise this stigma with negative effects on their mental health. While efforts to reduce public stigma are paramount, change can be slow, and interventions to prevent internalised stigma may also be needed. Using a mixed methods online survey, we gathered the views of 144 autistic adults and parents/caregivers of autistic people in the United Kingdom on whether a stigma-related support programme for autistic adults is needed and, if so, what it should ...˜look' like. Quantitative data (summarised descriptively) showed that most participants felt it was important for autistic adults to have support in managing stigma and revealed diverse preferences in terms of programme delivery, underscoring the need for flexibility. Using reflexive thematic analysis, four main themes were identified from the qualitative data: (1) ...˜We need to change society not autistic people', (2) ...˜Stigma is difficult to manage alone', (3) ...˜Focus on positive, practical support', and (4) ...˜There is no one size fits all approach'. We discuss the important implications our findings have for how future interventions in this area are framed and delivered.»...

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journals.sagepub

Protection de l'enfance : de nouveaux outils pour harmoniser les pratiques 05/01/2023

«En matière de protection de l'enfance, plusieurs nouveautés issues de la loi Taquet de février 2022 entrent en vigueur en ce début d'année 2023 : l'approbation du référentiel de la HAS comme cadre de référence d'évaluation des informations préoccupantes, la possibilité pour les départements d'expérimenter avec l'Etat un comité départemental pour la protection de l'enfance ou encore le démarrage du GIP "France enfance protégée" réunissant le 119, l'Observatoire national de la protection de l'enfance, l'Agence française de l'adoption et les secrétariats des trois conseils nationaux de l'accès aux origines personnelles, de l'adoption et de la protection de l'enfance. Tour d'horizon des différents textes réglementaires concernés.»...

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banquedesterritoires

La population des enfants suivis en protection de l’enfance au 31 décembre 2020 : les disparités départementales 04/01/2023


«1 2. Les évolutions des taux de prise en charge départementaux : des disparités en augmentation L’évolution des taux de prise en charge des mineurs et jeunes majeurs protégés, toutes prestations et mesures confondues (milieu ouvert et accueil) montrent des écarts entre départements, qui non seulement perdurent, mais se creusent entre 2010 et 2020, aussi bien en ce qui concerne les mineurs protégés que l’accompagnement des jeunes majeurs.» [...]
« Des écarts de prise en charge des mineurs qui s’accentuent Entre 2010 et 2020, toutes prestations et mesures confondues, les écarts se sont creusés entre départements. Ainsi, au 31 décembre 2020, le taux de prise en charge des mineurs (suivis en milieu ouvert ou accueillis) varie, selon les départements, de 11,7‰ (Yvelines) à 48,6‰ (Creuse), avec une valeur médiane estimée à 26,1 ‰ ; au 31 décembre 2010, les variations allaient de 9,3 ‰ (Guyane) à 39,2 ‰ (Hautes-Pyrénées). Au 31 décembre 2020, les départements des Yvelines, de Guyane, des Hauts-de-Seine, du Val-deMarne, de la Haute-Savoie, du Val-d’Oise et de l’Ain enregistrent les taux de prise en charge les plus faibles (moins de 15 ‰). À l’inverse, ces taux sont supérieurs à 30 ‰ dans 34 départements,la Creuse et la Nièvre ayant les taux les plus importants, respectivement 48,6 ‰ et 47,8 ‰. »...

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onpe.gouv

Decret n° 2022-1773 du 30 decembre 2022 relatif au tarif horaire minimal de l'aide a domicile mentionne au I de l'article L. 314-2-1 du code de l'action sociale et des familles pour l'annee 2023 - Legifrance 31/12/2022

«Article 1I.
• Au titre de l'année 2023, le montant du concours mentionné au e) du 3° de l'article L. 14-10-5 du code de l'action sociale et des familles dans sa rédaction issue de l'article 44 de la loi du 23 décembre 2021 susvisée, dénommé Md, attribué à chaque département au titre des surcouts d'allocation personnalisée d'autonomie et de prestation de compensation du handicap liés à l'application du tarif horaire minimal mentionné au I de l'article L. 314-2-1 du même code, est calculé selon la formule suivante :Md2023 = Md2022+ [(Tmin - TdAPA) × NdAPA × (1 - RdAPA) ] + [ (Tmin - TdPCH) × NdPCH × (1 - RdPCH)]où :»
[...]
«- Md2022 est le montant du concours versé au département par la Caisse nationale de solidarité pour l'autonomie au titre de l'année 2022 déterminé en application du décret du 28 avril 2022 susvisé ;
• Tmin est la valeur, en vigueur au 1er janvier 2023, du tarif horaire minimal mentionné au premier alinéa ;
• TdAPA est égal à la moyenne, pondérée par le volume horaire des prestations rendues en 2022, des tarifs horaires en vigueur au 1er septembre 2022, fixés par le département, dans le cadre de l'attribution de l'allocation personnalisée d'autonomie, pour la couverture du coût de ces mêmes prestations rendues par les services mentionnés à l'article L. 313-1-3 du même code aux personnes bénéficiant du droit à ces allocations, lorsque ces tarifs sont inférieurs au tarif minimal mentionné au premier alinéa ;
• TdPCH est égal à la moyenne, pondérée par le volume horaire des prestations rendues en 2022, des tarifs horaires en vigueur au 1er septembre 2022, fixés par le département, dans le cadre de l'attribution de la prestation de compensation du handicap, pour la couverture du coût de ces mêmes prestations rendues par les services mentionnés à l'article L. 313-1-3 du même code aux personnes bénéficiant du droit à ces allocations, lorsque ces tarifs sont inférieurs au tarif minimal mentionné au premier alinéa ;
• NdAPA est égal au volume horaire total des prestations, rendues dans le département en 2022, dans le cadre de l'allocation personnalisées d'autonomie, pour lesquelles les tarifs horaires fixés par le département et applicables au 1er septembre 2022 sont inférieurs au tarif minimal mentionné au premier alinéa ;
• NdPCH est égal au volume horaire total des prestations, rendues dans le département en 2022, dans le cadre de la prestation de compensation du handicap, pour lesquelles les tarifs horaires fixés par le département et applicables au 1er septembre 2022 sont inférieurs au tarif minimal mentionné au premier alinéa ;
• RdAPA est le taux moyen, en 2022, de la participation financière des personnes, ayant recours aux services mentionnés à l'article L. 313-1-3 du même code, aux dépenses relevant des plans d'aide élaborés dans le cadre de l'attribution de l'allocation personnalisée d'autonomie ;
• RdPCH est le taux moyen, en 2022, de la participation financière des personnes, ayant recours aux services mentionnés à l'article L. 313-1-3 du même code, aux dépenses relevant des plans d'aide élaborés dans le cadre de la prestation de compensation du handicap. II. - Chaque département communique à la Caisse nationale de solidarité pour l'autonomie le 30 juin 2023 au plus tard, par voie dématérialisée et selon des modalités fixées par cette caisse, les données mentionnées aux six derniers alinéas du I. Sous réserve que le département lui ait communiqué les données mentionnées à l'alinéa précédent à la date du 30 juin 2023, la Caisse nationale de solidarité pour l'autonomie procède au calcul du concours définitif dû à chaque département et à sa notification au plus tard le 30 septembre 2023. Les départements communiquent également à la caisse, à sa demande, toute information nécessaire à l'exercice de sa mission de versement du concours mentionné au présent article. »...

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legifrance.gouv

Un lien entre la perte auditive et les troubles du spectre autistique | Le Club 22/12/2022

«MEF2C, un gène essentiel au développement du cerveau et à la régulation de la formation des circuits dans le cerveau, joue également un rôle important dans le développement de l'oreille interne. Des mutations de MEF2C ont déjà été associées à des TSA. Les chercheurs ont constaté que les souris ne possédant qu'une seule copie du gène MEF2C présentaient une activité réduite du nerf auditif. "Comprendre comment ce gène peut participer au développement de l'oreille et comment le développement de l'oreille interne affecte le développement du cerveau a d'énormes possibilités d'application", a déclaré Cowan.»
[...]
«Les résultats de cette étude pourraient être importants non seulement pour les patients déficients en MEF2C, mais aussi pour les personnes autistes ou malentendantes en général. "Comprendre comment ce gène peut participer au développement de l'oreille et comment le développement de l'oreille interne affecte le développement du cerveau a d'énormes possibilités d'application", a déclaré Cowan. Dans des études futures, les chercheurs souhaitent découvrir comment MEF2C provoque exactement les changements qui ont été identifiés dans cette étude. L'équipe de recherche espère également explorer ces résultats chez les patients présentant une déficience en MEF2C en utilisant des tests auditifs non invasifs. »...

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blogs.mediapart

A Link Between Hearing Loss and Autism Spectrum Disorder - Neuroscience News 21/12/2022

«Summary: MEF2C, a gene critical for brain development and regulating circuit formation in the brain also plays a significant role in inner ear development. Mutations of MEF2C have previously been linked to ASD. Researchers found mice with only one copy of the MEF2C gene had reduced activity in the auditory nerve.Source: Medical University of South CarolinaA cross-disciplinary team of researchers in the College of Medicine at the Medical University of South Carolina (MUSC) has discovered hearing impairment in a preclinical model of autism spectrum disorder (ASD).More specifically, the researchers report in the Journal of Neuroscience that they observed mild hearing loss and defects in auditory nerve function.Closer examination of the nerve tissue revealed abnormal supportive cells called glia, aging-like degeneration and inflammation. The findings from this study highlight the importance of considering sensory organs and their interactions with the brain in understanding ASD.»...

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neurosciencenews

Intense World Theory Of Autism Explained Simply 13/12/2022

«Intense world theory of autism is supported by the fact that autistic brains produce 42 percent more information at rest.The brains of autistic children produce, on average, 42 percent more information than non-autistic children when in a resting state, a study has found (Velázquez & Galán, 2013).This may explain why children with autism tend to withdraw into their own inner world and become socially detached.»...

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spring.org

La decouverte pourrait conduire a des cibles therapeutiques pour traiter l'hyperphagie boulimique et l'obesite - Actualites Psychologie et psychiatrie 13/12/2022


«Près de 3% des Américains souffrent de troubles de l'hyperphagie boulimique à un moment donné de leur vie, et parmi eux, plus de huit sur 10 ont survécu à des abus, à de la négligence ou à d'autres traumatismes pendant leur enfance.Maintenant, un scientifique de Virginia Tech a identifié comment un traumatisme précoce peut modifier le cerveau pour augmenter le risque de crises de boulimie plus tard dans la vie.Les recherches menées par le chercheur principal Sora Shin, professeur adjoint au Fralin Biomedical Research Institute du VTC, ont révélé comment une voie cérébrale qui fournit généralement des signaux pour arrêter de manger peut être altérée par un traumatisme précoce.»...

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actualite.housseniawriting

Trouble du spectre autistique : un mecanisme de compensation pourrait etre present dans certains neurones 09/12/2022


«On parle de spectre, parce que l'autisme prend de nombreuses formes différentes...¦ Il s'agit d'un trouble neuro-développemental très précoce...¦ qui commence in utero et qui touche à la communication entre neurones. C'est ce qu'on appelle les synapses. Pour faire passer une information ou au contraire le stopper, le neurone va sécréter des molécules par sa synapsne...¦. et la synapse suivante va capter ces neurotransmetteurs avec des récepteurs, et faire passer au neurone suivant. Et ce que l'on sait, c'est que les TSA touchent certains neurones particuliers et un type de neurotransmetteurs particulier...¦ les neurones à glutamate...¦»...

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radiofrance

Trouble du spectre autistique : un mecanisme de compensation pourrait etre present dans certains neurones 09/12/2022


«On parle de spectre, parce que l'autisme prend de nombreuses formes différentes...¦ Il s'agit d'un trouble neuro-développemental très précoce...¦ qui commence in utero et qui touche à la communication entre neurones. C'est ce qu'on appelle les synapses. Pour faire passer une information ou au contraire le stopper, le neurone va sécréter des molécules par sa synapsne...¦. et la synapse suivante va capter ces neurotransmetteurs avec des récepteurs, et faire passer au neurone suivant. Et ce que l'on sait, c'est que les TSA touchent certains neurones particuliers et un type de neurotransmetteurs particulier...¦ les neurones à glutamate...¦»...

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radiofrance

Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways - Lefebvre - Autism Research - Wiley Online Library 07/12/2022

«AbstractAs an integral part of autism spectrum symptoms, sensory processing issues including both hypo and hyper sensory sensitivities. These sensory specificities may result from an excitation/inhibition imbalance with a poorly understood of their level of convergence with genetic alterations in GABA-ergic and glutamatergic pathways. In our study, we aimed to characterize the hypo/hyper-sensory profile among autistic individuals. We then explored its link with the burden of deleterious mutations in a subset of individuals with available whole-genome sequencing data. To characterize the hypo/hyper-sensory profile, the differential Short Sensory Profile (dSSP) was defined as a normalized and centralized hypo/hypersensitivity ratio from the Short Sensory Profile (SSP). Including 1136 participants (533 autistic individuals, 210 first-degree relatives, and 267 controls) from two independent study samples (PARIS and LEAP), we observed a statistically significant dSSP mean difference between autistic individuals and controls, driven mostly by a high dSSP variability, with an intermediated profile represented by relatives. Our genetic analysis tended to associate the dSSP and the hyposensitivity with mutations of the GABAergic pathway. The major limitation was the dSSP difficulty to discriminate subjects with a similar quantum of hypo- and hyper-sensory symptoms to those with no such symptoms, resulting both in a similar ratio score of 0. However, the dSSP could be a relevant clinical score, and combined with additional sensory descriptions, genetics and endophenotypic substrates, will improve the exploration of the underlying neurobiological mechanisms of sensory processing differences in autism spectrum.»...

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onlinelibrary.wiley

Autism related language preferences of English speaking individuals across the globe: A mixed methods investigation - Keating - Autism Research - Wiley Online Library 07/12/2022

«AbstractOver the past two decades, there have been increasing discussions around which terms should be used to talk about autism. Whilst these discussions have largely revolved around the suitability of identity-first language and person-first language, more recently this debate has broadened to encompass other autism-related terminology (e.g., ...˜high-functioning'). To date, academic studies have not investigated the language preferences of autistic individuals outside of the United Kingdom or Australia, nor have they compared levels of endorsement across countries. Hence, the current study adopted a mixed-methods approach, employing both quantitative and qualitative techniques, to explore the linguistic preferences of 654 English-speaking autistic adults across the globe. Despite variation in levels of endorsement between countries, we found that the most popular terms were similar...”the terms ...˜Autism', ...˜Autistic person', ...˜Is autistic', ...˜Neurological/Brain Difference', ...˜Differences', ...˜Challenges', ...˜Difficulties', ...˜Neurotypical people', and ...˜Neurotypicals' were consistently favored across countries. Despite relative consensus across groups, both our quantitative and qualitative data demonstrate that there is no universally accepted way to talk about autism. Our thematic analysis revealed the reasons underlying participants' preferences, generating six core themes, and illuminated an important guiding principle...”to respect personal preferences. These findings have significant implications for informing practice, research and language policy worldwide.»...

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onlinelibrary.wiley

Neuromagnetic 40 Hz auditory steady-state response in the left auditory cortex is related to language comprehension in children with autism spectrum disorder - PubMed 06/12/2022

«Abstract Language impairment is comorbid in most children with Autism Spectrum Disorder (ASD), but its neural mechanisms are still poorly understood. Some studies hypothesize that the atypical low-level sensory perception in the auditory cortex accounts for the abnormal language development in these children. One of the potential non-invasive measures of such low-level perception can be the cortical gamma-band oscillations registered with magnetoencephalography (MEG), and 40 Hz Auditory Steady-State Response (40 Hz ASSR) is a reliable paradigm for eliciting auditory gamma response. Although there is research in children with and without ASD using 40 Hz ASSR, nothing is known about the relationship between this auditory response in children with ASD and their language abilities measured directly in formal assessment. In the present study, we used MEG and individual brain models to investigate 40 Hz ASSR in primary-school-aged children with and without ASD. It was also used to assess how the strength of the auditory response is related to language abilities of children with ASD, their non-verbal IQ, and social functioning. A total of 40 children were included in the study. The results demonstrated that 40 Hz ASSR was reduced in the right auditory cortex in children with ASD when comparing them to typically developing controls. Importantly, our study provides the first evidence of the association between 40 Hz ASSR in the language-dominant left auditory cortex and language comprehension in children with ASD. This link was domain-specific because the other brain-behavior correlations were non-significant.»...

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pubmed.ncbi.nlm.nih

Elemental Dynamics in Hair Accurately Predict Future Autism Spectrum Disorder Diagnosis: An International Multi-Center Study 02/12/2022


«Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition diagnosed in approximately 2% of children. Reliance on the emergence of clinically observable behavioral patterns only delays the mean age of diagnosis to approximately 4 years. However, neural pathways critical to language and social functions develop during infancy, and current diagnostic protocols miss the age when therapy would be most effective. We developed non-invasive ASD biomarkers using mass spectrometry analyses of elemental metabolism in single hair strands, coupled with machine learning. We undertook a national prospective study in Japan, where hair samples were collected at 1 month and clinical diagnosis was undertaken at 4 years. Next, we analyzed a national sample of Swedish twins and, in our third study, participants from a specialist ASD center in the US. In a blinded analysis, a predictive algorithm detected ASD risk as early as 1 month with 96.4% sensitivity, 75.4% specificity, and 81.4% accuracy (n = 486; 175 cases). These findings emphasize that the dynamics in elemental metabolism are systemically dysregulated in autism, and these signatures can be detected and leveraged in hair samples to predict the emergence of ASD as early as 1 month of age.»...

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mdpi

Elemental Dynamics in Hair Accurately Predict Future Autism Spectrum Disorder Diagnosis: An International Multi-Center Study 02/12/2022


«Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition diagnosed in approximately 2% of children. Reliance on the emergence of clinically observable behavioral patterns only delays the mean age of diagnosis to approximately 4 years. However, neural pathways critical to language and social functions develop during infancy, and current diagnostic protocols miss the age when therapy would be most effective. We developed non-invasive ASD biomarkers using mass spectrometry analyses of elemental metabolism in single hair strands, coupled with machine learning. We undertook a national prospective study in Japan, where hair samples were collected at 1 month and clinical diagnosis was undertaken at 4 years. Next, we analyzed a national sample of Swedish twins and, in our third study, participants from a specialist ASD center in the US. In a blinded analysis, a predictive algorithm detected ASD risk as early as 1 month with 96.4% sensitivity, 75.4% specificity, and 81.4% accuracy (n = 486; 175 cases). These findings emphasize that the dynamics in elemental metabolism are systemically dysregulated in autism, and these signatures can be detected and leveraged in hair samples to predict the emergence of ASD as early as 1 month of age.»...

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mdpi

Elemental Dynamics in Hair Accurately Predict Future Autism Spectrum Disorder Diagnosis: An International Multi-Center Study 02/12/2022


«Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition diagnosed in approximately 2% of children. Reliance on the emergence of clinically observable behavioral patterns only delays the mean age of diagnosis to approximately 4 years. However, neural pathways critical to language and social functions develop during infancy, and current diagnostic protocols miss the age when therapy would be most effective. We developed non-invasive ASD biomarkers using mass spectrometry analyses of elemental metabolism in single hair strands, coupled with machine learning. We undertook a national prospective study in Japan, where hair samples were collected at 1 month and clinical diagnosis was undertaken at 4 years. Next, we analyzed a national sample of Swedish twins and, in our third study, participants from a specialist ASD center in the US. In a blinded analysis, a predictive algorithm detected ASD risk as early as 1 month with 96.4% sensitivity, 75.4% specificity, and 81.4% accuracy (n = 486; 175 cases). These findings emphasize that the dynamics in elemental metabolism are systemically dysregulated in autism, and these signatures can be detected and leveraged in hair samples to predict the emergence of ASD as early as 1 month of age.»...

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mdpi

New approaches to clinical electroencephalography analysis in typically developing children and children with autism - ScienceDirect 02/12/2022

«Abstract Clinical analysis of EEG is time-consuming and requires a high level of expertise. In this study, we developed a new approach for EEG analysis applying quantitative methods for assessing clinical indices of EEG for four age groups of children with severe autism spectrum disorder (ASD) and four age- and non-verbal IQ-matched groups of typically developing (TD) children. The new approach showed higher sensitivity and ASD-TD differences than conventional quantitative EEG analysis. TD and ASD groups had similar dispersions of EEG power spectral density, coherence, and peak alpha frequency, but the groups differed in the index, frequency variability, and instantaneous prevailing frequency of sensorimotor rhythm (SMR). The ASD-TD difference in SMR index and instantaneous prevailing frequency disappeared by the age of ten years. The ASD-TD differences in SMR frequency variability were most prominent in children younger than 4 and older than 10 years.»...

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sciencedirect

*** Relations between language, non-verbal cognition, and conceptualization in non- or minimally verbal individuals with ASD across the lifespan - Dominika Slusna, Andrea Rodriguez, Berta Salvado, Agustin Vicente, Wolfram Hinzen, 2021 30/11/2022

«Abstract Background & aimsIndividuals with non- or minimally verbal autism (nvASD) are primarily characterized by a severe speech production deficit, with speech limited to no or only a few words by school age. Significant unclarity remains over variability in language profiles across the lifespan, the nature of the language impairment seen, and (dis-) associations between linguistic and nonverbal cognitive measures.»
[...]
«Methods To address these questions, we recruited both a school-age and an adult group with nvASD (total N = 49) and investigated relations between expressive and receptive language, and between these and nonverbal intelligence quotient (NVIQ) and sense-making capacities (the ComFor test). Results Results revealed limited variation across this sample in receptive language, which in turn predicted expressive language levels. Importantly, an upward trend in verbal mental age (VMA) across increasing chronological age was seen in the youngsters (only). A radical dissociation between NVIQ and both expressive and receptive language transpired as well, and a subset of individuals with normal NVIQ were comparable in terms of any other cognitive aspect. Sense-making reached symbolic levels in 62.2% of the sample and loaded on both verbal and nonverbal factors. Conclusions These patterns inform theories of nvASD by revealing an impairment that is not conceptualizable as one of expressive language only, sharply limits learning opportunities across the lifespan, and cannot be compensated for by nonverbal cognition. Implications These findings stress the need to seize developmental opportunities that may disappear when youngsters turn into adults, via therapies that specifically target language as a central cognitive system comprising both production and comprehension. »...

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journals.sagepub

Social Gene and Anti-Social Antibiotic Uncovered in Animal Study May Aid Autism Research 29/11/2022

«The combined activities of an evolutionarily conserved enzyme and a regulatory protein control the expression of several genes that regulate the embryonic inception of sociability, claims an animal study published in the journal Science Advances on November 23, 2022. As part of this study, a team of scientists at the University of Utah screened 1,120 drugs and found that inhibiting the activity of Top2a (topoisomerase IIα) created lasting deficits in social behaviors in zebrafish, that normally develop a strong preference for fish their own age by three weeks of age.»
[...]
«“This study helps us understand at the molecular level why sociability is disrupted during the very earliest stages of life,” said Randall Peterson, PhD, the corresponding author of the study and dean of the University of Utah College of Pharmacy. “It also gives us an opportunity to explore potential treatments that could restore sociability in these animals and, perhaps in time, eventually in humans as well.” The insights from mice and zebrafish studies suggest exposure to certain antibiotics called fluoroquinolones during embryonic development inhibits Top2a expression, leading to alterations in social behavior that are similar to those found in individuals with autism. The researchers also found inhibition of the Top2a-interacting regulatory protein (PRC2, polycomb repressive complex 2) rescued social deficits caused by exposure to the antibiotic. The study indicates, Top2a controls a large network of genes, known to increase the risk of autism. It also may serve as a link between genetic and environmental factors that contribute to the onset of social impairments, added Peterson. »...

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genengnews

GUIDE PRATIQUE -Association des Maires de France AGIR POUR L’INCLUSION DES PERSONNES AUTISTES 28/11/2022

«GUIDE PRATIQUE -Association des Maires de France AGIR POUR L’INCLUSION DES PERSONNES AUTISTES Novembre 2022 1. Mieux comprendre l’autisme........................................................................................4 1. Qu’est-ce que l’autisme ?..............................................................................................................4 2. Chaque commune peut agir pour l’inclusion ................................................................................5 3. Les partenaires à mobiliser ..........................................................................................................6 2. Agir concrètement pour favoriser l’inclusion....................................................7 1. Comment agir dès le plus jeune âge ?...........................................................................................7 2. Inclure les enfants autistes à l’école et autour de l’école ..............................................................9 3. Avoir une politique globale en faveur des personnes en situation de handicap ...........................12 4. Favoriser l’accès aux soins et au bien-être des personnes autistes ............................................14 5. Comment soutenir l’emploi des adultes autistes ?......................................................................15 6. Aider l’accès à un logement des personnes autistes ...................................................................17 7. Adapter la mobilité et les espaces publics aux personnes autistes .............................................18 8. Pour un accès aux activités physiques et culturelles des personnes autistes ............................18 9. Accès aux droits et participation à la vie démocratique ..............................................................20 10. Aider les aidants ......................................................................................................................21 Glossaire ............................................................................................................................................22 Contacts des associations ..............................................................................................................22 Textes de référence..........................................................................................................................23 Remerciements..»...

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amf.asso

New evidence hints at mechanisms for ...˜fever effect' in autism | Spectrum | Autism Research News 16/11/2022

«Raising body temperature seems to alleviate seizures and other traits associated with two autism-linked genetic mutations in mice, according to unpublished research presented Sunday and Monday at Neuroscience 2022 in San Diego, California. The findings hint at a mechanism that could account for anecdotal reports that some autistic children have temporary improvements in sociability and other behaviors during or after a fever. Although about 17 percent of autistic children showed this ...˜fever effect' in a 2017 study based on parent reports, far fewer did when the same team of researchers followed autistic children prospectively.»...

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spectrumnews

Sensitivity to interaural level and time differences in individuals with autism spectrum disorder | Scientific Reports 11/11/2022

«Abstract Individuals with autism spectrum disorders (ASD) are reported to exhibit degraded performance in sound localization. This study investigated whether the sensitivity to the interaural level differences (ILDs) and interaural time differences (ITDs), major cues for horizontal sound localization, are affected in ASD. Thresholds for discriminating the ILD and ITD were measured for adults with ASD and age- and IQ-matched controls in a lateralization experiment. Results show that the ASD group exhibited higher ILD and ITD thresholds than the control group. Moreover, there was a significant diversity of ITD sensitivity in the ASD group, and it contained a larger proportion of participants with poor ITD sensitivity than the control group. The current study suggests that deficits in relatively low-level processes in the auditory pathway are implicated in degraded performance of sound localization in individuals with ASD. The results are consistent with the structural abnormalities and great variability in the morphology in the brainstem reported by neuroanatomical studies of ASD.»...

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nature

Eczema linked to increased symptom severity in children with autism spectrum disorder 07/11/2022

«Autism spectrum disorder (ASD) is a developmental disorder that can cause a range of social, behavioral, and communication challenges. A recent study found that children with ASD who also have an atopic condition such as eczema are more likely to have worse symptoms. The findings have been published in Translational Psychiatry. Eczema is a condition that causes the skin to become red, itchy, and inflamed. It is also known as atopic dermatitis. Eczema is a chronic condition that can be difficult to manage. The exact cause of atopic eczema is unknown, but it is thought to be caused by a combination of genetic and environmental factors. "There is an interesting overlap between eczema and neurodevelopmental conditions that warrants further investigation," said study author Adam Guastella, the Michael Crouch Chair in Child and Youth Mental Health at the University of Sydney. "We have long known that children with neurodevelopmental conditions often have a higher rate of eczema and allergies. There has been limited research to show whether having eczema and atopic diseases is also linked to more severe symptoms of neurodevelopmental conditions. Understanding this link better may provide leads into detection and intervention opportunities that can support both conditions.»
[...]
« Guastella and his colleagues found that children presenting with an atopic comorbidity tended to have more severe autism symptoms, as measured via the Autism Diagnostic Observation Schedule. The findings provide evidence “that there is an interesting relationship with skin conditions and autism symptoms that requires further evaluation,” he told PsyPost. “It seems that those children with eczema in particular also have more severe symptoms of neurodevelopmental delay. We need to understand why. It may lead to opportunities for earlier detection and supports to improve outcomes for both developmental processes.” “Having an eczema (or atopic disease broadly) more than doubled a child’s chance of scoring on the severe end of autism symptoms and social difficulty symptoms, as rated by clinicians,” Guastella noted. “That was a big jump that warrants further investigation. While there has long been acknowledgement that kids with neurodevelopmental condition have a higher rate of skin conditions, this is one of the first to suggest a link with the severity of autism symptoms.” The main limitation of the study is the cross-sectional nature of the data. The link between atopic conditions and autism severity could be “incidental,” Guastella said. “Research examining causal pathways are required.” »...

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psypost